In mild doses, it dries the skin and peels it. This side effect has been used to prepare derivatives of Vitamin A called retinoids. Vitamin a is also called retinol. Its derivatives are called retinoids. Isotretinoin is the most famous derivative. Others are tretinoin, Adapalene , tazarotene .

Acne treatment with Vitamin A derivatives

Topical Vitamin A derivatives dry the skin and peel the upper layers off. This quality is very useful in treating acne. Sebum, the skin oil is the most responsible for causing acne. This sebum becomes infected and forms acne. Vitamin A derivatives dry out this sebum on the site of application. The other main cause of acne formation is blocked sebaceous glands. Once the top layer begins peeling because of Vitamin a derivatives, the pores open. This effectively cures acne.